Clinical study demonstrates continuous kidney enlargement correlates with renal function decline in ADPKD, suggesting volume progression tracks disease severity.
Kidney enlargement resulting from the expansion of cysts in patients with ADPKD is continuous and quantifiable and is associated with the decline of renal function. Higher rates of kidney enlargement are associated with a more rapid decrease in renal function.
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Grantham et al. (2006) studied this question.
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