Chromatin Remodeling Induced by ARID1A Loss in Lung Cancer Promotes Glycolysis and Confers JQ1 Vulnerability

Xiaoyu Liu; Zhi Li; Zhongmin Wang; Fei Liu; Linling Zhang; Jingjing Ke; Xu Xu; Yuefang Zhang; Yiting Yuan; Tao Wei; Qungang Shan; Yingjie Chen; Wei Huang; Jie Gao; Nan Wu; Fuliang Chen; Lunquan Sun; Zilong Qiu; Yuezhen Deng; Xiaojing Wang

doi:10.1158/0008-5472.can-21-0763

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Abstract

This study links ARID1A loss with enhanced glycolysis in lung cancer and demonstrates the preclinical efficacy of BET inhibitor therapy as a strategy to combat tumor growth.

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Liu et al. (2022) studied this question.

synapsesocial.com/papers/69db099037b5141e3ba3cc6c https://doi.org/10.1158/0008-5472.can-21-0763

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Chromatin Remodeling Induced by ARID1A Loss in Lung Cancer Promotes Glycolysis and Confers JQ1 Vulnerability

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Abstract

Discussion

Cite This Study

Chromatin Remodeling Induced by ARID1A Loss in Lung Cancer Promotes Glycolysis and Confers JQ1 Vulnerability

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Abstract

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Cite This Study

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