Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho‐associated coiled‐coil protein kinase 1

Transgenic mice expressing truncated Rho-associated coiled-coil protein kinase 1 (ROCKΔ1) in cardiomyocytes, kinase-deficient control mice, and isolated cardiac fibroblasts and cardiomyocytes.

Expression of ROCKΔ1 in cardiomyocytes; exposure to angiotensin II stress; treatment with Rho kinase inhibitor, TGFβR1 inhibitor, or NF-κB inhibitor.

Kinase-deficient mice; wild-type cardiomyocytes.

Development of fibrotic cardiomyopathy and diastolic dysfunction.surrogate