November 1, 2005CirculationOpen Access

Decreased Perivascular Fibrosis but Not Cardiac Hypertrophy in ROCK1 +/− Haploinsufficient Mice

View Full Paper

Ask AI

Bookmark

Why the study?

Does ROCK1 haploinsufficiency reduce cardiac hypertrophy and fibrosis in response to pathological conditions in mice?

Structured PICO

Does ROCK1 haploinsufficiency reduce cardiac hypertrophy and fibrosis in response to pathological conditions in mice?

Population

ROCK1+/- haploinsufficient mice on C57Bl/6 background

Intervention

Pathological stimuli including angiotensin II infusion (400 ng/kg/min for 28 days), NG-nitro-L-arginine methyl ester (1 mg/mL in drinking water for 28 days), transaortic constriction, or myocardial infarction

Comparator

Wild-type (WT) littermates exposed to the same pathological stimuli

Outcome

Cardiac hypertrophy (systolic blood pressure, left ventricular wall thickness, left ventricular mass, ratio of heart weight to tibial length, cardiomyocyte size) and perivascular fibrosissurrogate

ROCK1 haploinsufficiency attenuates cardiac fibrosis but not hypertrophy in response to pathological stress, indicating distinct signaling pathways for these responses.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Suggests ROCK1 as selective antifibrotic target in cardiac stress; leaves open translation to human disease.

Cite This Study

Rikitake et al. (2005) studied this question.

synapsesocial.com/papers/6a6fb991f44fa9f079dd329d https://doi.org/10.1161/circulationaha.105.584623

View Full Paper

Ask AI

Bookmark

Decreased Perivascular Fibrosis but Not Cardiac Hypertrophy in ROCK1 +/− Haploinsufficient Mice

Structured PICO

Discussion

Implication

Cite This Study

Decreased Perivascular Fibrosis but Not Cardiac Hypertrophy in ROCK1 +/− Haploinsufficient Mice

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider