Why the study?
Does the use of selective COX-2 inhibitors and nonselective NSAIDs increase the risk of death or reinfarction in patients with previous acute myocardial infarction?
Does the use of selective COX-2 inhibitors and nonselective NSAIDs increase the risk of death or reinfarction in patients with previous acute myocardial infarction?
Selective COX-2 inhibitors and high-dose nonselective NSAIDs are associated with increased mortality in patients with a history of myocardial infarction and should be used with caution.
May warrant caution with these agents post-MI; extends observational data but leaves causality and practice change open.
Selective COX-2 inhibitors in all dosages and nonselective NSAIDs in high dosages increase mortality in patients with previous MI and should therefore be used with particular caution in these patients.
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Gislason et al. (2006) studied this question.
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