Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 13, 2000JAMA

Gastrointestinal Toxicity With Celecoxib vs Nonsteroidal Anti-inflammatory Drugs for Osteoarthritis and Rheumatoid Arthritis

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does celecoxib reduce the incidence of symptomatic ulcers and ulcer complications compared to standard NSAIDs in patients with osteoarthritis and rheumatoid arthritis?

Population

Patients with osteoarthritis and rheumatoid arthritis

Comparison

Celecoxib at dosages greater than those… vs Nonsteroidal anti-inflammatory drugs at standard…

Authors

FSFred E. SilversteinPDK InternationalGFGerald A. FaichBoston UniversityJGJay L. GoldsteinNorthwestern University

Discussion

Loading...

Member takes

Implication

Supports celecoxib over standard NSAIDs to reduce GI toxicity in arthritis; confirms RCT safety advantage.

Structured PICO

Does celecoxib reduce the incidence of symptomatic ulcers and ulcer complications compared to standard NSAIDs in patients with osteoarthritis and rheumatoid arthritis?

P
Population
Patients with osteoarthritis and rheumatoid arthritis
I
Intervention
Celecoxib at dosages greater than those indicated clinically
C
Comparator
Nonsteroidal anti-inflammatory drugs (NSAIDs) at standard dosages
O
Outcome
Incidence of symptomatic ulcers and ulcer complications combinedsafety

Celecoxib at supratherapeutic doses is associated with lower upper gastrointestinal toxicity compared to standard-dose NSAIDs, particularly in patients not taking aspirin.

Cite This Study

Silverstein et al. (2000) studied this question.

synapsesocial.com/papers/69dc384e4f901957bec0fd8dhttps://doi.org/10.1001/jama.284.10.1247
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Basic biology and clinical application of specific cyclooxygenase-2 inhibitors2000 · 296 citations
  2. 2The gastrointestinal toxicity of aspirin: an overview of randomised controlled trials.1993 · 296 citations
  3. 3Prophylactic aspirin and risk of peptic ulcer bleeding1995 · 568 citations
  4. 4Individual Nonsteroidal Antiinflammatory Drugs and Other Risk Factors for Upper Gastrointestinal Bleeding and Perforation1997 · 227 citations
  5. 5Risk of aspirin-associated major upper-gastrointestinal bleeding with enteric-coated or buffered product1996 · 419 citations