September 18, 2023Open Access

Exo-miR-1290-induced by COX-2 overexpression promotes cancer-associated fibroblasts activation and tumor progression by CUL3-Nrf2 pathway in lung adenocarcinoma

XBXiaoming BaiPrecision for Medicine (United States)JSJiaofang ShaoNanjing Medical University TDTinghong DuanNanjing Medical University

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Abstract

Our data identify a new CAFs activation mechanism by exosomes derived from cancer cells that overexpress COX-2. Specifically, COX-2/exo-miR-1290/CUL3 is suggested as a novel signaling pathway for mediating CAFs activation and tumor progression in LUAD. Consequently, this finding suggests a novel strategy for cancer treatment that may tackle tumor progression in the future. Video Abstract.

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Bai et al. (Mon,) studied this question.

synapsesocial.com/papers/69db23277a67537a8ba3d030 https://doi.org/https://doi.org/10.1186/s12964-023-01268-0

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