Does TRIM18 regulate innate immunity and organ inflammation in viral-induced diseases?
TRIM18 is identified as a critical negative regulator of innate immunity in viral-induced diseases, presenting a potential therapeutic target for viral myocarditis.
Our results indicate that TRIM18 serves as a negative regulator of viral myocarditis, lung inflammation and brain damage by downregulating innate immune activation induced by both RNA and DNA viruses. Our data reveal that TRIM18 is a critical regulator of innate immunity in viral induced diseases, thereby identifying a potential therapeutic target for treatment.
Fang et al. (Sun,) studied this question.