September 1, 2024European Heart Journal Acute Cardiovascular Care15 citationsOpen Access

Do DanGer-SHOCK-like patients benefit from VA-ECMO treatment in infarct-related cardiogenic shock? results of an individual patient data meta-analysis

UZUwe ZeymerInterventional Cardiology AFAnne FreundHeart Failure & Transplant MHMatthias HochadelGeneral Cardiology

Structured PICO

Does routine use of VA-ECMO reduce mortality in patients with infarct-related cardiogenic shock, STEMI, and a low likelihood of brain injury?

Population

Patients with cardiogenic shock (CS), STEMI, and a low likelihood of brain injury (DanGer-SHOCK-like patients)

Intervention

Routine use of venoarterial extracorporeal membrane oxygenation (VA-ECMO)

Outcome

Mortalityhard clinical

In an individual patient data meta-analysis of DanGer-SHOCK-like patients, routine VA-ECMO did not show a mortality benefit, though the analysis was underpowered.

Abstract

In this exploratory subgroup analysis in patients with CS, STEMI, and a low likelihood of brain injury, there was no mortality benefit with the routine use of VA-ECMO. However, as indicated by the large confidence intervals, the statistical power was limited to draw definite conclusions.

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