Why the study?
Does nitric oxide inhibition with L-NMMA prevent insulin-induced vasodilation in healthy volunteers?
Population
Healthy volunteers
Comparison
NG-monomethyl-L-arginine infused into the… vs Baseline and norepinephrine
Design
Other
Follow-up
2 hours
Authors
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NO mediates insulin vasodilation without altering glucose uptake in healthy volunteers; leaves open relevance to hypertension or insulin resistance.
Does nitric oxide inhibition with L-NMMA prevent insulin-induced vasodilation in healthy volunteers?
Insulin's vasodilatory effects are mediated by stimulation of nitric oxide release, which helps regulate arterial pressure during physiologic hyperinsulinemia.
Scherrer et al. (1994) studied this question.
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