New and Bioactive Sesquiterpenes from Schisandra sphenanthera

This is the authors' abstract. We don't add key points for this paper.

Three new sesquiterpenes, schisansphenins A ( 1 ) and B ( 2 ) and (−)‐ γ ‐cuparenol ( 3 ), were isolated from an acetone extract of the fruits of Schisandra sphenanthera. The known compound 4 was isolated for the frist time from a natural source. The structures of the isolated compounds were elucidated through extensive spectroscopic analyses, particularly 2D‐NMR experiments ( 1 H, 1 H‐COSY, HMQC, HMBC, and NOESY). A plausible biogenetic pathway for schisansphenin B ( 2 ) is proposed. Compounds 2 and 3 significantly reduced activation of NF‐AT and NF‐ κ B in the luciferase‐reporter assay.