Experimental study demonstrates that low shear stress upregulates PCSK9 expression via reactive oxygen species in vascular cells, suggesting a mechanism for localized atherosclerosis.
This study provides evidence that low shear stress enhances PCSK9 expression in concert with ROS generation in vascular ECs and SMCs. ROS seem to regulate PCSK9 expression. We propose that PCSK9-ROS interaction may be important in the development of atherosclerosis in arterial channels with low shear stress.
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Ding et al. (2014) studied this question.
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