Key result
Disturbed flow along the lateral wall of the rabbit aorto-iliac bifurcation was associated with a higher rate of LDL incorporation compared to the medial wall (5.2 vs 3.7 nl/mg/hr, p<0.01).
Population
Rabbit aorto-iliac bifurcation model
Comparison
Disturbed flow vs Undisturbed flow
Design
Preclinical
Follow-up
20 hours
Authors
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May link disturbed flow to early atherogenesis via LDL uptake; hypothesis-generating in this animal model and leaves translation to humans open.
Absolute Event Rate: 5.2% vs 3.7%
p-value: p=<0.01
Hemodynamic forces, specifically disturbed flow, induce modifications in arterial wall LDL incorporation and catabolism, which may contribute to the formation of atherosclerotic lesions.
Berceli et al. (1990) studied Arterial wall LDL metabolism. Disturbed flow (lateral wall) vs. Undisturbed flow (medial wall) was evaluated on Rate of LDL incorporation (nl/mg/hr) (p=<0.01). Disturbed flow along the lateral wall of the rabbit aorto-iliac bifurcation was associated with a higher rate of LDL incorporation compared to the medial wall (5.2 vs 3.7 nl/mg/hr, p<0.01).
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