Key result
An atherogenic diet for 12 weeks significantly increased 125I-LDL uptake into the isolated rabbit carotid artery wall at high pressure-induced distension to 12.04% compared to 3.52% in controls.
Population
Isolated segments of rabbit carotid arteries
Design
Preclinical
Authors
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Atherogenic diet effects on LDL uptake predominate at high pressure in rabbit arteries; leaves open translation to human carotid atherosclerosis.
Absolute Event Rate: 12.04% vs 3.524%
p-value: p=<0.05
Shear stress dominates LDL uptake at low pressure, while atherogenic diet duration dominates at high pressure in isolated rabbit carotid arteries.
Colic et al. (2015) studied Atherosclerosis (n=20). Atherogenic diet (1% cholesterol) vs. Standard diet (control) was evaluated on 125I-LDL uptake at high pressure-induced distension (140 mmHg) (p=<0.05). An atherogenic diet for 12 weeks significantly increased 125I-LDL uptake into the isolated rabbit carotid artery wall at high pressure-induced distension to 12.04% compared to 3.52% in controls.
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