Key result
Perfusion of rabbit aorto-iliac bifurcations showed that DiI-LDL uptake peaked in branching areas for all flow conditions, with the highest overall uptake in the static group.
Population
Rabbit aorto-iliac bifurcation model
Comparison
Perfusion with 3,3'-dioctadecylindocarbocyanine-L… vs Static group (no flow)
Design
Preclinical
Authors
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Should not yet inform clinical decisions; leaves open relative contributions of shear stress and concentration polarization to human atherogenesis.
Both endothelial barrier function modulated by wall shear stress and LDL concentration polarization are involved in atherogenic lipid accumulation, with concentration polarization likely playing a larger role.
Ding et al. (2010) studied Atherogenesis. Perfusion flow conditions (forward, backward, static) vs. Static group was evaluated on DiI-LDL uptake distribution along the lateral wall of the bifurcation. Perfusion of rabbit aorto-iliac bifurcations showed that DiI-LDL uptake peaked in branching areas for all flow conditions, with the highest overall uptake in the static group.
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