April 1, 2017Journal of The Royal Society InterfaceOpen Access

Numerical simulation of haemodynamics and low-density lipoprotein transport in the rabbit aorta and their correlation with atherosclerotic plaque thickness

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Population

Rabbit aorta model (high-fat-diet rabbit)

Design

Preclinical

Authors

XLXiaoyin LiChina Tobacco XLXiao LiuArmy Medical University PZPeng ZhangQingdao University

Discussion

Member takes

Implication

Rabbit aorta simulations link LDL transport to plaque; extends mechanistic insights but leaves open human translation.

Structured PICO

Population

Rabbit aorta model (high-fat-diet rabbit)

Intervention

Computational fluid dynamics simulation of blood flow and LDL transport

Outcome

Correlation among low-density lipoproteins (LDL) transport, haemodynamic parameters and plaque thicknesssurrogate

LDL distribution is closely linked to blood flow transport, and the synergetic effects of luminal surface LDL concentration and wall shear stress-based haemodynamic indicators may determine atherosclerotic plaque thickness.

Cite This Study

Li et al. (2017) studied this question.

synapsesocial.com/papers/6a6fed76ce524a4339c3bf85 https://doi.org/10.1098/rsif.2017.0140

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Ask AI

Bookmark

Numerical simulation of haemodynamics and low-density lipoprotein transport in the rabbit aorta and their correlation with atherosclerotic plaque thickness

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Numerical simulation of haemodynamics and low-density lipoprotein transport in the rabbit aorta and their correlation with atherosclerotic plaque thickness

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider