What does this research mean for the field?

In a patient-specific computational model, hypertension, increased endothelial permeability, and elevated serum LDL levels significantly increase subendothelial LDL accumulation, particularly in downstream regions of stenosis characterized by flow recirculation and low endothelial shear stress. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

March 16, 2013AJP Heart and Circulatory PhysiologyOpen Access

Patient-specific computational modeling of subendothelial LDL accumulation in a stenosed right coronary artery: effect of hemodynamic and biological factors

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Population

Three-dimensional computational model of a stenosed right coronary artery reconstructed from angiographic…

Comparison

Computational modeling of blood flow and LDL… vs Reconstructed model of the same artery with…

Design

Preclinical

Authors

ASAntonis I. SakellariosUniversity of Patras MPMichail I. PapafaklisUniversity of Patras PSPanagiotis K. SiogkasUniversity of Ioannina

Discussion

Member takes

Implication

Supports CV risk factor synergy in computational models; leaves open translation to human atherosclerosis.

Structured PICO

Population

Three-dimensional computational model of a stenosed right coronary artery reconstructed from angiographic and intravascular ultrasound patient data

Intervention

Computational modeling of blood flow and LDL transport under varying hemodynamic and biological factors (hypertension, increased endothelial permeability, increased serum LDL levels)

Comparator

Reconstructed model of the same artery with restored patency (nondiseased state)

Outcome

Local endothelial shear stress (ESS) distribution and subendothelial LDL accumulationsurrogate

Computational modeling demonstrates that coronary stenosis, hypertension, endothelial dysfunction, and elevated LDL synergistically promote subendothelial LDL accumulation, supporting their roles as major cardiovascular risk factors.

Cite This Study

Sakellarios et al. (2013) studied this question.

synapsesocial.com/papers/6a1bca70d54006be995efccf https://doi.org/10.1152/ajpheart.00539.2012

Topics

Hypertension management

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Patient-specific computational modeling of subendothelial LDL accumulation in a stenosed right coronary artery: effect of hemodynamic and biological factors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Patient-specific computational modeling of subendothelial LDL accumulation in a stenosed right coronary artery: effect of hemodynamic and biological factors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider