Key result
Endothelial removal increased steady-state LDL uptake in isolated rabbit carotid arteries to 9.2%, almost 3 times higher than with intact endothelium (p<0.05).
Population
Isolated left and right common carotid arteries from New Zealand White rabbits of both sexes, weighing 3.5-4…
Comparison
Perfusion with 125I-LDL under high pressure and… vs Perfusion under lower pressure and with intact…
Design
Preclinical
Authors
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Endothelial integrity may limit arterial LDL uptake; leaves open relevance to human atherosclerosis.
p-value: p=<0.05
An ex vivo experimental model demonstrates that LDL uptake by the arterial wall is significantly increased by higher perfusion pressure and endothelial damage.
Maja et al. (2012) studied Atherosclerosis (experimental model) (n=5). Endothelium removal vs. Intact endothelium was evaluated on Steady state uptake (Us) of 125I-LDL (p=<0.05). Endothelial removal increased steady-state LDL uptake in isolated rabbit carotid arteries to 9.2%, almost 3 times higher than with intact endothelium (p<0.05).
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