April 1, 1991AJP Heart and Circulatory Physiology

Quantitative analysis of blood vessel permeability of squirrel monkeys

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Population

Squirrel monkeys; analysis of 87 vascular regions representing 280 transmural profiles.

Design

Preclinical

Authors

RTRonald G. TompkinsRutgers, The State University of New Jersey

Discussion

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Implication

Hypothesis-generating for permeability-driven LDL uptake in primates; leaves open translation to human atherosclerosis.

Structured PICO

Population

Squirrel monkeys (primates that develop diet-induced atherosclerosis similar to humans); analysis of 87 vascular regions representing 280 transmural profiles.

Intervention

Mathematical transport model analyzing in vivo low-density lipoprotein (LDL) transport across the aorta, peripheral muscular arteries, and major veins.

Outcome

Intimal mass transfer coefficient (k1) and effective diffusion coefficient.surrogate

Focal regions of enhanced LDL uptake in the vasculature of squirrel monkeys are driven primarily by increased intimal permeability rather than diffusion.

Cite This Study

Ronald G. Tompkins (1991) studied this question.

synapsesocial.com/papers/6a917aa1ca59a4cbdea168ed https://doi.org/10.1152/ajpheart.1991.260.4.h1194

View Full Paper

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Quantitative analysis of blood vessel permeability of squirrel monkeys

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Quantitative analysis of blood vessel permeability of squirrel monkeys

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider