Key result
Diet-induced fatty streaks in Cynomolgus monkeys were associated with a higher mean influx rate of low density lipoprotein compared to controls (69 vs 28 nl.cm-2 per hour, p<0.001).
Why the study?
Does diet-induced fatty streak formation alter the arterial wall uptake and efflux of low density lipoprotein in Cynomolgus monkeys?
Population
Cynomolgus monkeys with diet-induced fatty streaks and control monkeys
Comparison
Diet-induced fatty streak formation vs Control monkeys
Design
Preclinical
Authors
Loading...
May increase intimal LDL permeability in early lesions; leaves open efflux failure mechanisms in human atherosclerosis.
Does diet-induced fatty streak formation alter the arterial wall uptake and efflux of low density lipoprotein in Cynomolgus monkeys?
Absolute Event Rate: 69% vs 28%
p-value: p=<0.001
Intimal permeability to LDL is increased at the fatty streak stage of lesion formation, suggesting relative failure of efflux is a major cause of excess LDL accumulation in hypercholesterolemia.
Ghosh et al. (1987) studied Diet induced fatty streaks. Diet induced fatty streaks vs. Controls was evaluated on Mean influx rate of low density lipoprotein (nl.cm-2 per hour) (p=<0.001). Diet-induced fatty streaks in Cynomolgus monkeys were associated with a higher mean influx rate of low density lipoprotein compared to controls (69 vs 28 nl.cm-2 per hour, p<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: