November 1, 1987Proceedings of the National Academy of SciencesOpen Access

Genomic RNAs of influenza viruses are held in a circular conformation in virions and in infected cells by a terminal panhandle.

View Full Paper

Ask AI

Bookmark

Population

Influenza virions and influenza virus-infected cells

Design

Preclinical

Authors

MHM T HsuNational Health Research Institutes JPJeffrey D. ParvinThe Ohio State University SGSasha GuptaUniversity of California, San Francisco

Discussion

Member takes

Implication

Hypothesis-generating for panhandle-targeted antivirals in influenza; leaves open validation in mammalian models before any clinical consideration.

Structured PICO

Population

Influenza virions and influenza virus-infected cells

Intervention

Psoralen crosslinking methods (4'-aminomethyltrioxsalen [AMT]), electron microscopy, RNA blot analysis, and nuclease S1 protection assays

Outcome

Conformation of viral RNA segmentssurrogate

The terminal panhandle structure of influenza viral RNA maintains a circular conformation, which may act as a cis regulatory signal for mRNA synthesis and packaging.

Cite This Study

Hsu et al. (1987) studied this question.

synapsesocial.com/papers/69db2c3e78a3e0e2886850df https://doi.org/10.1073/pnas.84.22.8140

View Full Paper

Ask AI

Bookmark

Implication

Hypothesis-generating for panhandle-targeted antivirals in influenza; leaves open validation in mammalian models before any clinical consideration.

Genomic RNAs of influenza viruses are held in a circular conformation in virions and in infected cells by a terminal panhandle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Genomic RNAs of influenza viruses are held in a circular conformation in virions and in infected cells by a terminal panhandle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider