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April 12, 2026Frontiers in Cell and Developmental BiologyOpen Access

The role of long non-coding RNAs in therapy resistance of cervical cancer and therapeutic potential

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Authors

ZHZhenglin HeHHHaiping HaoXLXuechao Li

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Overview

This review demonstrates how long non-coding RNAs drive therapy resistance in cervical cancer, suggesting novel diagnostic and therapeutic pathways.

Key Points

  • To explore how long non-coding RNAs contribute to therapy resistance in cervical cancer and their potential as therapeutic targets.
  • Review of literature on lncRNAs and their roles in therapy resistance in cervical cancer.
  • Analysis of mechanisms of lncRNA action, including ceRNA activity and pathway modulation.
  • Evaluation of lncRNAs as biomarkers and therapeutic targets in clinical applications.
  • Identification of specific lncRNAs associated with resistance to chemotherapy, radiotherapy, and immunotherapy.
  • Demonstration of lncRNAs acting as ceRNAs that sponge tumor-suppressive microRNAs.
  • Highlighting the potential for lncRNA-targeted therapies using ASOs and CRISPR techniques.

Cite This Study

He et al. (2026) studied this question.

synapsesocial.com/papers/69db35be4fe01fead37c43cehttps://doi.org/10.3389/fcell.2026.1746979
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long noncoding RNAs involved in therapeutic response: implications for cervical cancer drug resistance2025
  2. 2lncRNAs as Targetable Nodes of Oncogenic Networks Underlying Cancer Progression and Therapy Resistance2025
  3. 3lncRNAs as Targetable Nodes of Oncogenic Networks Underlying Cancer Progression and Therapy Resistance2025
  4. 4Long non-coding RNAs in cancer stem cells and therapeutic resistance2026
  5. 5Long Non-Coding RNAs in HER2-Positive Breast Cancer: From Resistance Mechanisms to Translational Potential2026