Liposarcomas of the hypopharynx: A case report

Liposarcoma of the hypopharynx is extremely rare. We report a 66-year-old male who presented with a six-month history of throat foreign body sensation and progressive dysphagia. Laryngoscopy revealed a smooth, mucosa-covered mass on the posterior hypopharyngeal wall. MRI demonstrated a 3.3 cm cystic mass with heterogeneous enhancement. Transoral endoscopic laser resection was performed. Histopathology and FISH confirmed well-differentiated liposarcoma with MDM2 amplification. No adjuvant therapy was given. The patient resumed oral feeding within one week. At two-year follow-up, he remained free of dysphagia, respiratory, or speech impairment, and endoscopy showed no recurrence. This case highlights diagnostic challenges, the necessity of MDM2 FISH testing, and the importance of long-term surveillance.