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April 12, 2026SHILAP Revista de lepidopterologíaOpen Access

mRNA vaccines in oncology: personalized cancer immunization and neoantigen targeting

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Authors

MPMridula ParganihaJRJaishriram RathoredDPDeepika Sai Painkra

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Overview

Systematic review reveals improved recurrence-free survival with mRNA vaccines in oncology, suggesting innovative strategies for personalized immunotherapy.

Key Points

  • To evaluate the efficacy and mechanisms of personalized mRNA neoantigen vaccines in oncology.
  • Review of clinical trials from 2020 to 2025
  • Analysis of mRNA-4157 combined with pembrolizumab
  • Evaluation of the autogene cevumeran in pancreatic ductal adenocarcinoma
  • Focus on tumor clonality and immune responses
  • Assessment of real-world challenges in mRNA vaccine implementation
  • mRNA-4157 improved recurrence-free survival in high-risk melanoma (18-month RFS 79% vs 62%)
  • Autogene cevumeran elicited T cell responses in 50% of patients with delayed recurrence
  • Indicators like minimal residual disease are crucial for clinical success
  • Highlighted the importance of tumor antigen quality and immune accessibility

Cite This Study

Parganiha et al. (2026) studied this question.

synapsesocial.com/papers/69db35be4fe01fead37c43fdhttps://doi.org/10.1080/23723556.2026.2652613
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Next-generation neoantigen mRNA vaccines: Immuno-engineering strategies for precision cancer immunotherapy2026 · 10 citations
  2. 2Next-Generation mRNA Vaccines in Melanoma: Advances in Delivery and Combination Strategies2025 · 20 citations
  3. 3mRNA Cancer Vaccines: From Pandemic Paradigm to Personalized Oncology Therapeutics2025 · 11 citations
  4. 4Neoantigen in cancer immunotherapy: mechanism, therapeutic strategies and future perspectives2026
  5. 5Neoantigen-driven cancer vaccines: Revolutionizing precision oncology through personalized immunotherapy2025 · 1 citations