Key result
Older age, lower BMI, and higher frailty are linked to lower grip strength trajectories in CVD.
Why the study?
What are the clinical determinants of grip strength trajectories in middle-aged and older Chinese patients with cardiovascular disease?
Cohort (n=2,189)
Yes
What are the clinical determinants of grip strength trajectories in middle-aged and older Chinese patients with cardiovascular disease?
Longitudinal grip strength monitoring may help identify high-risk middle-aged and older patients with cardiovascular disease, as older age, lower BMI, and higher frailty index predict a low grip strength trajectory.
May warrant longitudinal grip strength monitoring to identify high-risk CVD patients; hypothesis-generating for frailty-targeted prevention trials.
This study revealed three GS trajectories among patients with CVD, with older age, lower BMI, and higher FI emerging as robust determinants of the low GS trajectory. These findings highlight the potential value of longitudinal GS monitoring for identifying high-risk individuals. Whether interventions targeting modifiable factors such as nutritional status and frailty can influence GS trajectories and subsequent clinical outcomes warrants further investigation.
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Su et al. (2026) conducted a cohort in Cardiovascular disease (n=2,189). Low- and middle-level grip strength trajectories vs. High-level grip strength trajectory was evaluated on Determinants of trajectory group membership (p=<0.05). Older age, lower BMI, and higher frailty index were significantly associated with low- and middle-level grip strength trajectories compared to the high-level trajectory in patients with CVD.
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