Case reports demonstrate that urticaria and angioedema signal underlying malignancies, highlighting the need for thorough screening.
Urticaria and angioedema are common conditions evaluated by allergists. Still, their potential association with lymphoproliferative and myeloproliferative conditions underscores the importance of screening for red-flag syndromes and performing an appropriate workup. Here, we present the case of a 57-year-old woman who presented with seemingly idiopathic angioedema and urticaria that was partially responsive to standard antihistamine therapy but was found to have an underlying malignancy and whose symptoms greatly improved with treatment of the driving condition.
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Kafashzadeh et al. (2026) studied this question.
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