What question did this study set out to answer?

The aim is to develop a sensitive method for screening diuretics in weight loss dietary supplements.

Optimisation and validation of a GC-MS method for screening for diuretics in adulterated weight loss dietary supplements

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This work demonstrates a validated method for detecting diuretics in dietary supplements, indicating enhanced consumer safety.

The aim is to develop a sensitive method for screening diuretics in weight loss dietary supplements.
Developed a gas chromatography-mass spectrometry method for detecting 14 diuretics.
Optimised using selected ion monitoring and SCAN mode for confirmation.
Validated according to ICH guidelines with specific focus on detection limits and extraction efficiency.
Applied the method to 10 dietary supplement samples from the Tunisian market.
Detection limits for solid matrices ranged from 15.68 to 160.83 ng/g and from 3.31 to 21.69 ng/mL for liquid matrices.
Extraction efficiency rates were between 65% and 95%.
Intra-day and inter-day precision were below 8%, with accuracy ranging from 79% to 114%.
None of the tested products contained the investigated diuretics.

Trabelsi et al. (2026) studied this question.

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