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April 9, 2026Journal of PerinatologyOpen Access

Does inhaled nitric oxide treatment of pulmonary hypertension in extremely premature infants improve patient outcomes?

Tyler L. King Patrick J. McNamara Adrianne R. Bischoff

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Implication

Randomized control trial examines whether inhaled nitric oxide improves outcomes in extremely premature infants, suggesting potential benefits.

Abstract

QUESTIONDoes inhaled nitric oxide (iNO) treatment for early echocardiographic pulmonary hypertension (PH) decrease the risk of death or bronchopulmonary dysplasia (BPD) in extremely preterm infants? METHODS DesignSingle-center double-blinded randomized control trial (RCT). PatientsInfants born less than or equal to 29 weeks' gestation who received positive pressure ventilation at 72 24 postnatal hours were eligible.

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Cite This Study

King et al. (2026) studied this question.

synapsesocial.com/papers/69db36a04fe01fead37c4a20 https://doi.org/10.1038/s41372-026-02666-1

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Inhaled nitric oxide in preterm infants: An updated meta-analysisMeta-Analysis · 2016 · 15 citations
2Inhaled nitric oxide in preterm infants with respiratory disease: a systematic review and meta-analysis2025 · 1 citations
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4NIH Consensus Development Conference Statement: Inhaled Nitric-Oxide Therapy for Premature InfantsRCT · 2011 · 211 citations
5Effect of early adjunctive use of oral sildenafil and inhaled nitric oxide on the outcome of pulmonary hypertension in newborn infants. A feasibility studyRCT · 2016 · 25 citations

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