Advanced Hybrid Closed Loop Systems in Pregnancy: A Retrospective Study of Women With Type 1 Diabetes

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Key Points

This study aims to evaluate the effectiveness and safety of hybrid closed loop systems (HCLS) in managing type 1 diabetes during pregnancy.
Conducted a retrospective analysis of women with type 1 diabetes using HCLS during pregnancy.
Assessed glycemic control through time in range (TIR) and time below range (TBR) metrics.
Monitored frequency of diabetic ketoacidosis (DKA) episodes.
66% of participants achieved at least 70% time in range (TIR) during pregnancy.
Reported low time below range (TBR), indicating effective glucose control.
No episodes of diabetic ketoacidosis (DKA) occurred in the cohort.

Retrospective study shows HCLS improves blood sugar control in women with type 1 diabetes during pregnancy, suggesting safety and effectiveness.

In our cohort, HCLS in pregnancy was effective, with 66% achieving ≥ 70% TIRp, and appears to be safe with low TBR and no episodes of DKA.

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Stathi et al. (2026) studied this question.

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