What question did this study set out to answer?

To develop a modular strategy for achieving high enantioselectivity in asymmetric alkyne transformations using gold and organocatalysts.

April 12, 2026Accounts of Chemical Research

Asymmetric Alkyne Transformation via Gold/Organo Synergistic Catalysis

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MBMing Bao MYMinghan Yao LQLixin Qian

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Overview

This account demonstrates asymmetric transformations in alkyne chemistry via synergistic gold/organo catalysis, suggesting practical pathways for synthesizing chiral molecules.

Key Points

To develop a modular strategy for achieving high enantioselectivity in asymmetric alkyne transformations using gold and organocatalysts.
Utilized gold-catalyzed oxidative generation of gold carbenes from alkynes.
Conducted asymmetric carbene geminal difunctionalization using chiral Brønsted acids.
Isolated and characterized allylic gold species for asymmetric ene-type reactions.
Employed chiral organocatalysts to enhance enantioselectivity in various reactions.
Achieved diverse asymmetric transformations leading to chiral dihydrofuran-3-ones and ketones.
Isolated a key allylic gold intermediate for the first time, enabling new reaction pathways.
Demonstrated high stereocontrol in reactions facilitated by chiral organocatalysts.
Established a flexible, modular approach using readily available catalysts for diverse alkyne transformations.

Cite This Study

Bao et al. (2026) studied this question.

synapsesocial.com/papers/69db37404fe01fead37c53ce https://doi.org/10.1021/acs.accounts.6c00075

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April 12, 2026Accounts of Chemical Research

Asymmetric Alkyne Transformation via Gold/Organo Synergistic Catalysis

View Full Paper

Ask AI

Bookmark

Authors

MBMing Bao MYMinghan Yao LQLixin Qian

Discussion

Member takes

Overview

This account demonstrates asymmetric transformations in alkyne chemistry via synergistic gold/organo catalysis, suggesting practical pathways for synthesizing chiral molecules.

Key Points

To develop a modular strategy for achieving high enantioselectivity in asymmetric alkyne transformations using gold and organocatalysts.
Utilized gold-catalyzed oxidative generation of gold carbenes from alkynes.
Conducted asymmetric carbene geminal difunctionalization using chiral Brønsted acids.
Isolated and characterized allylic gold species for asymmetric ene-type reactions.
Employed chiral organocatalysts to enhance enantioselectivity in various reactions.
Achieved diverse asymmetric transformations leading to chiral dihydrofuran-3-ones and ketones.
Isolated a key allylic gold intermediate for the first time, enabling new reaction pathways.
Demonstrated high stereocontrol in reactions facilitated by chiral organocatalysts.
Established a flexible, modular approach using readily available catalysts for diverse alkyne transformations.

Cite This Study

Bao et al. (2026) studied this question.

synapsesocial.com/papers/69db37404fe01fead37c53ce https://doi.org/10.1021/acs.accounts.6c00075

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