The Small Molecule Compound Eupalinolide B Ameliorates Depressive Behaviors and Neuropathic Pain in Mice With Spared Nerve Injury: Integrating Network Pharmacology, Molecular Docking, Bioinformatics, Molecular Dynamics Simulation and Experimental Verification

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The aim is to explore how eupalinolide B alleviates depressive behaviors and neuropathic pain in mice.
Utilized network pharmacology to identify molecular targets.
Performed molecular docking to investigate binding interactions.
Conducted bioinformatics analyses for protein expression profiles.
Applied molecular dynamics simulations to assess stability of complexes.
Validated findings through experimental verification in animal models.
Eupalinolide B reduced expression levels of EGFR and PTGS2 proteins.
Improved synaptic plasticity in the observed mice.
Alleviated both depressive behaviors and neuropathic pain caused by nerve injury.

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Demonstrates that eupalinolide B alleviates neuroinflammation and improves pain-depression comorbidity in mice, suggesting its therapeutic potential.

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Yang et al. (2026) studied this question.

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