Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 12, 2026Blood Purification

Exploring the Impact of Expanded Hemodialysis with Super High-Flux Dialyzer on Inflammation and Gene Expression: A Prospective Cohort Study in Prevalent Hemodialysis Patients

View Full Paper
Ask AI
Bookmark
Share

Authors

TTTheerachai ThammathiwatBrigham and Women's HospitalTATantip ArigulSiriraj HospitalTWThidathip WongsurawatSiriraj Hospital

Discussion

Loading...

Member takes

Implication

Prospective cohort study demonstrates reduced inflammation in prevalent hemodialysis patients after high-efficiency HDx, suggesting immune benefits.

Key Points

  • This research aims to examine the effects of expanded hemodialysis with a super high-flux dialyzer on inflammation and gene expression in patients with end-stage kidney disease.
  • Conducted a single-center pilot study on 10 prevalent hemodialysis patients.
  • Assessed patients at baseline on standard high-flux hemodialysis and after 12 months on high-efficiency HDx with an SHF dialyzer.
  • Performed RNA sequencing on peripheral blood mononuclear cells (PBMC).
  • Quantified serum cytokines and chemokines using a multiplex immunoassay.
  • 12 out of 43 analyzed genes showed significant upregulation after 12 months of HDx, particularly TNF and CCL4.
  • Serum inflammatory markers TNF-α, CCL4, CCL2, and MMP-9 significantly declined, while IL-10 increased.
  • Quantitative changes included TNF-α levels increasing from 26.9 to 31.5 pg/mL and CCL4 from 22.7 to 32.5 pg/mL.

Cite This Study

Thammathiwat et al. (2026) studied this question.

synapsesocial.com/papers/69db37b04fe01fead37c5bd4https://doi.org/10.1159/000551822
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Haemodiafiltration and mortality in end-stage kidney disease patients: a pooled individual participant data analysis from four randomized controlled trials2015 · 297 citations
  2. 2Causes of Death in End-Stage Kidney Disease: Comparison between the United States Renal Data System and a Large Integrated Health Care System2022 · 75 citations
  3. 3Molecular changes associated with increased TNF-α-induced apoptotis in naïve (TN) and central memory (TCM) CD8+ T cells in aged humans2018 · 17 citations
  4. 4Emerging role of chemokine CC motif ligand 4 related mechanisms in diabetes mellitus and cardiovascular disease: friends or foes?2016 · 97 citations
  5. 5RNA Sequencing Data: Hitchhiker's Guide to Expression Analysis2019 · 176 citations