What question did this study set out to answer?

This research aims to evaluate the anti-inflammatory properties of the hydroethanolic extract of C. regium xylopodium and identify its phytochemical constituents.

April 12, 2026InflammopharmacologyOpen Access

Chemical profile and anti-inflammatory activity of the hydroethanolic extract of Cochlospermum regium (Schrank) Pilg. xylopodium

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Authors

JMJéssica de Araújo Isaías MullerUniversidade Federal de Mato Grosso BSBruna Fioravante Di SerioUniversidade Federal de Mato Grosso FFFabiana de Freitas FigueiredoUniversidade Federal de Mato Grosso

Discussion

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Implication

Examines the anti-inflammatory effects of Cochlospermum regium extract in mice and cells, suggesting its therapeutic potential.

Key Points

This research aims to evaluate the anti-inflammatory properties of the hydroethanolic extract of C. regium xylopodium and identify its phytochemical constituents.
Prepared a 70% hydroethanolic extract from C. regium xylopodium.
Conducted in vivo assays in male Swiss mice using vascular permeability and LPS-induced peritonitis models.
Performed in vitro experiments on RAW 264.7 macrophages to assess cytotoxicity and inflammatory responses.
HECr reduced Evans blue extravasation in the vascular permeability assay.
In LPS-induced peritonitis, it decreased total leukocyte and neutrophil migration, and reduced TNF-α and IL-1β levels while increasing IL-10.
In macrophages, HECr decreased IL-1β and NO production, and showed no cytotoxicity.

Cite This Study

Muller et al. (2026) studied this question.

synapsesocial.com/papers/69db37b04fe01fead37c5bfe https://doi.org/10.1007/s10787-026-02227-0

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April 12, 2026InflammopharmacologyOpen Access

Chemical profile and anti-inflammatory activity of the hydroethanolic extract of Cochlospermum regium (Schrank) Pilg. xylopodium

View Full Paper

Ask AI

Bookmark

Authors

Discussion

Member takes

Implication

Examines the anti-inflammatory effects of Cochlospermum regium extract in mice and cells, suggesting its therapeutic potential.

Key Points

This research aims to evaluate the anti-inflammatory properties of the hydroethanolic extract of C. regium xylopodium and identify its phytochemical constituents.
Prepared a 70% hydroethanolic extract from C. regium xylopodium.
Conducted in vivo assays in male Swiss mice using vascular permeability and LPS-induced peritonitis models.
Performed in vitro experiments on RAW 264.7 macrophages to assess cytotoxicity and inflammatory responses.
HECr reduced Evans blue extravasation in the vascular permeability assay.
In LPS-induced peritonitis, it decreased total leukocyte and neutrophil migration, and reduced TNF-α and IL-1β levels while increasing IL-10.
In macrophages, HECr decreased IL-1β and NO production, and showed no cytotoxicity.

Cite This Study

Muller et al. (2026) studied this question.

synapsesocial.com/papers/69db37b04fe01fead37c5bfe https://doi.org/10.1007/s10787-026-02227-0

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