What question did this study set out to answer?

This research aims to evaluate the anti-inflammatory properties of the hydroethanolic extract of C. regium xylopodium and identify its phytochemical constituents.

April 12, 2026InflammopharmacologyOpen Access

Chemical profile and anti-inflammatory activity of the hydroethanolic extract of Cochlospermum regium (Schrank) Pilg. xylopodium

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Authors

JMJéssica de Araújo Isaías Muller BSBruna Fioravante Di Serio FFFabiana de Freitas Figueiredo

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Overview

Examines the anti-inflammatory effects of Cochlospermum regium extract in mice and cells, suggesting its therapeutic potential.

Key Points

This research aims to evaluate the anti-inflammatory properties of the hydroethanolic extract of C. regium xylopodium and identify its phytochemical constituents.
Prepared a 70% hydroethanolic extract from C. regium xylopodium.
Conducted in vivo assays in male Swiss mice using vascular permeability and LPS-induced peritonitis models.
Performed in vitro experiments on RAW 264.7 macrophages to assess cytotoxicity and inflammatory responses.
HECr reduced Evans blue extravasation in the vascular permeability assay.
In LPS-induced peritonitis, it decreased total leukocyte and neutrophil migration, and reduced TNF-α and IL-1β levels while increasing IL-10.
In macrophages, HECr decreased IL-1β and NO production, and showed no cytotoxicity.

Cite This Study

Muller et al. (2026) studied this question.

synapsesocial.com/papers/69db37b04fe01fead37c5bfe https://doi.org/10.1007/s10787-026-02227-0

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April 12, 2026InflammopharmacologyOpen Access

Chemical profile and anti-inflammatory activity of the hydroethanolic extract of Cochlospermum regium (Schrank) Pilg. xylopodium

View Full Paper

Ask AI

Bookmark

Authors

JMJéssica de Araújo Isaías Muller BSBruna Fioravante Di Serio FFFabiana de Freitas Figueiredo

Discussion

Member takes

Overview

Examines the anti-inflammatory effects of Cochlospermum regium extract in mice and cells, suggesting its therapeutic potential.

Key Points

This research aims to evaluate the anti-inflammatory properties of the hydroethanolic extract of C. regium xylopodium and identify its phytochemical constituents.
Prepared a 70% hydroethanolic extract from C. regium xylopodium.
Conducted in vivo assays in male Swiss mice using vascular permeability and LPS-induced peritonitis models.
Performed in vitro experiments on RAW 264.7 macrophages to assess cytotoxicity and inflammatory responses.
HECr reduced Evans blue extravasation in the vascular permeability assay.
In LPS-induced peritonitis, it decreased total leukocyte and neutrophil migration, and reduced TNF-α and IL-1β levels while increasing IL-10.
In macrophages, HECr decreased IL-1β and NO production, and showed no cytotoxicity.

Cite This Study

Muller et al. (2026) studied this question.

synapsesocial.com/papers/69db37b04fe01fead37c5bfe https://doi.org/10.1007/s10787-026-02227-0

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