In vivo study demonstrates CAR-mRNA reprograms macrophages to suppress tumor growth in melanoma, indicating new therapeutic approaches.
We demonstrate that macrophage-targeted MPLA-LNP delivery of TYRP1-CAR mRNA in a murine choroidal melanoma model reprograms tumor-associated macrophages toward an M1 phenotype, suppresses tumor growth, and prolongs survival through combined antigen-specific targeting and microenvironment remodeling.
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Chen et al. (2026) studied this question.
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