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April 12, 2026Journal of Structural Chemistry0 citations

New Oxcarbazepine Solvate(10,11-dihydro-10-oxo-5H-dibenzb,fazepine-5-carboxamide) with Chloroform: Crystallization, Stability, and Crystal Structure Analysis

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DZD. Ya. ZheltikovaELE. A. LosevEBE. V. Boldyreva

Key Points

  • To investigate the crystallization, stability, and molecular structure of oxcarbazepine solvate with chloroform.
  • Grew crystals for single crystal X-ray diffraction analysis
  • Developed a reproducible procedure for solvate creation
  • Analyzed intermolecular interactions in the crystal structure
  • Conducted powder XRD analysis during desolvation
  • Identified main types of intermolecular interactions in the molecular packing
  • Noted formation of new unstable phases during desolvation
  • Observed transformation to thermodynamically stable polymorph I of oxcarbazepine

Abstract

Crystals suitable for the single crystal X-ray diffraction (XRD) analysis oxcarbazepine (OxCBZ) solvate with chloroform are grown for the first time. A procedure is proposed to reproducibly obtain this solvate. The crystal structure solution enables the determination of the main types of intermolecular interactions stabilizing the molecular packing. The powder XRD analysis shows that during desolvation new unstable phases form, which are prone to transformation to thermodynamically stable I polymorph OxCBZ.

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Cite This Study

Zheltikova et al. (2026) studied this question.

synapsesocial.com/papers/69db37ca4fe01fead37c5da4https://doi.org/10.1134/s0022476626030017
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