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The aim is to explore the effects of spermidine on gene expression and muscle function in an ALS mouse model.

April 12, 2026BiomoleculesOpen Access

Transcriptomic Analysis Reveals the Beneficial Effects of Spermidine in an ALS Mouse Model

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Transcriptomic analysis reveals spermidine's potential to improve muscle strength and gene expression in ALS mice, suggesting therapeutic avenues.

The aim is to explore the effects of spermidine on gene expression and muscle function in an ALS mouse model.
Conducted gene expression analysis in spinal cord and gastrocnemius tissue of SOD1-G93A ALS mice.
Administered spermidine to ALS mice and assessed gene expression changes.
Performed Seahorse experiments to evaluate mitochondrial bioenergetics.
Monitored muscle strength using grip strength tests.
Spermidine treatment restored the expression of over four thousand genes in gastrocnemius tissue.
Significant improvement in mitochondrial respiration was observed after spermidine treatment.
Grip strength tests indicated delayed muscle weakness in treated ALS mice.

Fiorucci et al. (2026) studied this question.

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Transcriptomic analysis reveals spermidine's potential to improve muscle strength and gene expression in ALS mice, suggesting therapeutic avenues.