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April 12, 2026Journal of Cancer Research and PracticeOpen Access

Impact of Early versus Delayed G-CSF Administration on Clinical Outcomes in Chemotherapy-induced Neutropenia: A Propensity Score-matching Cohort Study

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Authors

HLHsieh-Ting LinKoo Foundation Sun Yat-Sen Cancer CenterLCLun-Wei ChiouKoo Foundation Sun Yat-Sen Cancer CenterNCNei-Min ChuKoo Foundation Sun Yat-Sen Cancer Center

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Implication

Cohort study evaluates early versus delayed G-CSF administration's impact on clinical outcomes in cancer treatment, suggesting early use improves results.

Key Points

  • This study aims to evaluate the clinical outcomes of early versus delayed administration of G-CSF in patients with chemotherapy-induced neutropenia.
  • Conducted as a retrospective cohort study.
  • Included patients with early-stage breast cancer receiving adjuvant chemotherapy.
  • Categorized patients by the timing of G-CSF administration: early (48–72 hours) versus delayed (>72 hours).
  • Applied propensity score matching to balance baseline characteristics, creating a matched cohort of 236 patients.
  • Assessed outcomes using Kaplan-Meier survival analysis and Cox proportional hazards models.
  • Early G-CSF administration significantly improved event-free survival (HR = 0.46, P < 0.001).
  • Fever-free survival also improved with early administration (HR = 0.36, P = 0.001).
  • Neutropenia-free survival was better in the early group (HR = 0.53, P = 0.003).
  • Sensitivity analyses confirmed the robustness of findings.

Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/69db380f4fe01fead37c629fhttps://doi.org/10.4103/ejcrp.ejcrp-d-25-00039
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