Blood transfusion (BT), red blood cell (RBC) transfusion, patient blood management (PBM), and transfusion-transmitted infections (TTIs) remain central to emergency and routine care in settings where access, safety, and logistics are constrained. Evidence gaps persist due to the cost and time requirements of TTI testing, limited ongoing surveillance within district systems, and diagnostic delays that shift decision-making away from laboratory thresholds. This narrative review aims to synthesise BT indications, operational challenges, and practical solutions relevant to decentralised and remote hospital environments. A structured literature synthesis was conducted using databases including PubMed, Scopus, and Google Scholar, applying predefined search terms related to BT practices, rural healthcare, and transfusion safety for studies published between 2015 and 2025; studies were selected based on relevance to clinical indications, logistical challenges, and safety outcomes in resource-limited settings. Key outcomes included comparative transfusion threshold findings in haemoglobinopathies and sepsis, the feasibility of universal-donor products in trauma, and the role of cold-chain and storage systems in maintaining supply integrity. Practice implications include prioritising physiological criteria for urgent BT when laboratory access is delayed, while strengthening governance through clinical audits and point-of-care electronic verification. The findings support integrated transfusion pathways that combine decentralised preparedness with mandatory pathogen screening and standardised monitoring frameworks. The central takeaway is that safe rural BT systems require coordinated investment in supply resilience, workforce competency, and technology-enabled verification, rather than reliance on isolated interventions.
Topno et al. (Thu,) studied this question.