This method demonstrates effective synthesis of dioxazepines in broad conditions, indicating enhanced synthetic versatility.
An efficient [4+3] cyclization strategy has been developed that exploits p ‐QMs and N ‐(EWG) nitrones generated in situ from N‐hydroxy(sulfonylmethyl)carbamates, enabling direct access to 1,4,2‐dioxazepines under mild conditions with broad substrate scope and gram‐scale scalability. This work expands the synthetic utility of N ‐(EWG) nitrones and offers a new route to dioxazepines.
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Shen et al. (2026) studied this question.
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