Randomized trial demonstrates effective synthesis of benzo[e][1,3]oxazin-2-ones, suggesting a new method for drug development.
An efficient and convenient [4 + 2] annulation between o-hydroxyphenyl-substituted p-quinone methides (p-QMs) and carbamates is developed for the construction of biologically useful benzo[e][1,3]oxazin-2-ones. This novel strategy is distinguished by mild reaction conditions, simple operation, broad substrate scope, excellent yields, accessible scalability, and practical transformations.
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Wang et al. (2026) studied this question.
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