Ligand field and polarity tuning of Fe(II) complexes for selective ROS-mediated anticancer activity †

Hyewon Lee; Lucia Wiwid Wijayanti; Hyungbin Park; Seungwoo Hong

doi:10.1039/d6cc00812g

January 1, 2026Chemical Communications

Ligand field and polarity tuning of Fe(II) complexes for selective ROS-mediated anticancer activity †

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Key Points

The aim is to enhance the anticancer properties of Fe(II) complexes through ligand modifications.
Designed a new N5-type ligand with improved donating ability and reduced polarity.
Synthesized Fe(II) complexes with the modified ligand.
Analyzed the electronic structure to assess shifts in π-π transitions.
The redesigned ligand significantly altered the metal-centered electronic structure.
Higher donor strength of the ligand led to improved selectivity in ROS-mediated effects against cancer cells.

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Implication

This research demonstrates enhanced selective ROS-mediated anticancer activity in Fe(II) complexes, suggesting novel therapeutic potential.

Abstract

A redesigned N5-type ligand that strengthens the donating ability while reducing polarity was utilized to generate an Fe(II) complex. This modification reorganized the metal-centered electronic structure, producing red-shifted π-π* and...

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Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/69db38274fe01fead37c6524 https://doi.org/10.1039/d6cc00812g

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Ligand field and polarity tuning of Fe(II) complexes for selective ROS-mediated anticancer activity †

Key Points

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Implication

Abstract

Discussion

Cite This Study

Ligand field and polarity tuning of Fe(II) complexes for selective ROS-mediated anticancer activity †

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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