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April 12, 2026Chemical Communications2 citations

Ligand field and polarity tuning of Fe(II) complexes for selective ROS-mediated anticancer activity †

HLHyewon LeeLWLucia Wiwid WijayantiHPHyungbin Park

Key Points

  • The aim is to enhance the anticancer properties of Fe(II) complexes through ligand modifications.
  • Designed a new N5-type ligand with improved donating ability and reduced polarity.
  • Synthesized Fe(II) complexes with the modified ligand.
  • Analyzed the electronic structure to assess shifts in π-π* transitions.
  • The redesigned ligand significantly altered the metal-centered electronic structure.
  • Higher donor strength of the ligand led to improved selectivity in ROS-mediated effects against cancer cells.

Abstract

A redesigned N5-type ligand that strengthens the donating ability while reducing polarity was utilized to generate an Fe(II) complex. This modification reorganized the metal-centered electronic structure, producing red-shifted π-π* and...

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Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/69db38274fe01fead37c6524https://doi.org/10.1039/d6cc00812g
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