Redox-responsive Fe(II)/Fe(III) MRI probes with pentadentate or hexadentate macrocyclic ligands

Deepak Krishnan Balaji; Joseph A. Spernyak; Matthew R. Crawley; Janet R Morrow

doi:10.1039/d6qi00660d

January 1, 2026Inorganic Chemistry FrontiersOpen Access

Redox-responsive Fe(II)/Fe(III) MRI probes with pentadentate or hexadentate macrocyclic ligands

View Full Paper

Ask AI

Bookmark

Share

Key Points

The aim is to explore Fe(II) complexes as agents for monitoring inflammation-related peroxide production.
Studied Fe(II) complexes of TACN with pendant groups.
Assessed the effectiveness of pentadentate vs hexadentate ligands.
One ligand demonstrated redox-responsiveness for effective monitoring.
Inflammation was indicated by changes in peroxide levels through the MRI probes.

Implication

This research shows how redox-responsive agents improve monitoring of inflammation by detecting peroxide levels.

Abstract

Fe(II) complexes of TACN (1,4,7-triazacyclononane) containing two 6-methyl-2-picolyl pendant groups are studied as redox-responsive agents for monitoring peroxide produced in inflammation. One Fe(II) complex has a pentadentate ligand with a...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Balaji et al. (2026) studied this question.

synapsesocial.com/papers/69fbefd5164b5133a91a3d60 https://doi.org/10.1039/d6qi00660d

View Full Paper

Ask AI

Bookmark

Share

Redox-responsive Fe(II)/Fe(III) MRI probes with pentadentate or hexadentate macrocyclic ligands

Key Points

Implication

Abstract

Discussion

Cite This Study

Redox-responsive Fe(II)/Fe(III) MRI probes with pentadentate or hexadentate macrocyclic ligands

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

More related papers

More from Inorganic Chemistry Frontiers

Keep reading

More related papers

More from Inorganic Chemistry Frontiers