A systematic review demonstrates that discontinuing MRAs does not impact outcomes in primary hyperaldosteronism, suggesting a patient-centered approach.
Concurrent use of MRA treatment did not adversely affect the diagnostic performance of AVS, rates of PA lateralization or postoperative outcomes. These results suggest that discontinuation of MRAs, despite being recommended by society guidelines, may not be necessary, and instead support a patient-centred approach to management of PA. Given the overall low quality of evidence, future prospective studies are needed to address this dilemma.
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Pérez‐Soto et al. (2026) studied this question.
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