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This analysis assesses lipid vulnerability to environmental stressors in mRNA-LNPs, indicating the need for improved stability measures.
The long-term stability of mRNA lipid nanoparticles (LNPs) is governed by the chemical resilience of their constituent lipids, yet the specific degradation pathways triggered by real-world stressors remain poorly defined.
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Girgis et al. (2026) studied this question.
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