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January 1, 2026Nanotechnology ReviewsOpen Access

Numerical investigation of IgG sensing through nanoscale topological-assisted metasurface for liquid biopsy

Carlotta Panciera Giuseppe Brunetti Caterina Ciminelli

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Key Points

The aim is to enhance sensitivity and robustness in biosensing through a novel topological photonics approach.
Developed a refractive-index sensor using a Jackiw-Rebbi topological resonance
Utilized normal-incidence transverse-magnetic excitation
Examined performance across a wavelength range of 870–970 nm
Analyzed bulk sensitivity and Q-factors
Achieved Q-factor greater than 1,600
Demonstrated bulk sensitivity of 97 nm/RIU
Obtained figure of merit of 1.7 × 10^5
Showed enhanced tolerance to fabrication variations

Implication

Numerical investigation reveals enhanced biosensing capabilities in liquid biopsy applications, suggesting improved diagnostic potential.

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Cite This Study

Panciera et al. (2026) studied this question.

synapsesocial.com/papers/69db38534fe01fead37c699d https://doi.org/10.1515/ntrev-2025-0284

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