Precursors of Age-Related Macular Degeneration: Associations With Physical Activity, Obesity, and Serum Lipids in the Inter99 Eye Study

Precursors of AMD were associated with modifiable obesity-related risk factors; notably low physical activity with drusen > 63 μm; and lower serum HDL and moderately elevated serum triglycerides with 20 or more small, hard macular drusen per eye. These findings support that a physically active, heart-healthy lifestyle prevents the earliest manifestation of AMD. (ClinicalTrials.gov number, NCT00289237.).