Why the study?
Does moxalactam affect blood coagulation and platelet function in normal male volunteers?
Population
5 normal male volunteers (in vivo study) and in vitro models
Design
Other
Follow-up
7 days
Authors
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May increase bleeding risk via platelet effects; leaves open contribution to clinical coagulopathy beyond vitamin K depletion.
Does moxalactam affect blood coagulation and platelet function in normal male volunteers?
Moxalactam suppresses ADP-induced platelet aggregation but does not directly inhibit clotting factors, suggesting bleeding complications are likely due to elimination of vitamin K-producing gut flora.
Bang et al. (1982) studied this question.
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