What question did this study set out to answer?

To review the signaling mechanisms of hypoxia-inducible factor-1α (HIF-1α) and synthesize its immunopathological contributions across various inflammatory autoimmune disorders.

January 25, 2023SHILAP Revista de lepidopterologíaOpen Access

Emerging role of hypoxia-inducible factor-1α in inflammatory autoimmune diseases: A comprehensive review

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Authors

YTYang‐Yang TangSouthwest Medical University DWDacheng WangNortheast Agricultural University YWYouqiang WangChangzhi University

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Implication

Narrative review reveals hypoxia-inducible factor-1α dysregulation across inflammatory autoimmune diseases, suggesting novel therapeutic targets for conditions like lupus and rheumatoid arthritis.

Key Points

To review the signaling mechanisms of hypoxia-inducible factor-1α (HIF-1α) and synthesize its immunopathological contributions across various inflammatory autoimmune disorders.
Narrative review evaluating biological and clinical evidence on HIF-1α expression across immune and non-immune cell lineages.
Examined mechanistic links between tissue microenvironment hypoxia, metabolic shifts, and disrupted immunological balance in autoimmune pathologies.
HIF-1α acts as a central metabolic sensor that is overexpressed and functionally dysregulated in diseases like systemic lupus erythematosus and rheumatoid arthritis.
Activation of HIF-1α signaling promotes the secretion of inflammatory cytokines and drives the proliferation of autoreactive immune and tissue-resident cells.

Cite This Study

Tang et al. (2023) studied this question.

synapsesocial.com/papers/69db757e5017fa0be2a3bffb https://doi.org/10.3389/fimmu.2022.1073971

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Implication

Narrative review reveals hypoxia-inducible factor-1α dysregulation across inflammatory autoimmune diseases, suggesting novel therapeutic targets for conditions like lupus and rheumatoid arthritis.

Emerging role of hypoxia-inducible factor-1α in inflammatory autoimmune diseases: A comprehensive review

Discussion

Member takes

Implication

Key Points

Cite This Study

Emerging role of hypoxia-inducible factor-1α in inflammatory autoimmune diseases: A comprehensive review

Discussion

Member takes

Implication

Key Points

Cite This Study

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