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In vitro study demonstrates that HMGB1/RAGE signaling drives keratinocyte proliferation and prevents apoptosis, highlighting its pathogenic contribution to cholesteatoma.
HMGB1 signaling engages multiple activation pathways in RAGE-positive keratinocytes. HMGB1 protects RAGE-positive keratinocytes from drug-induced apoptosis. Keratinocyte proliferation is controlled via RAGE and HMGB1 molecular signaling. Molecular signaling of the HMGB1/RAGE axis contributes to cholesteatoma pathogenesis.
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Szczepański et al. (2014) studied this question.
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