Diagnostic study reveals simplified screening reduces sensitivity for subtle monoclonal gammopathies without affecting multiple myeloma detection, highlighting trade-offs in panel selection.
The major impact of using a simplified screening panel of serum PEL plus FLC rather than PEL, IFE, and FLC is an 8% reduction in sensitivity for MGUS, 23% for POEMS (7 patients), 4% for plasmacytoma (1 patient), 1% for AL, and 0.5% for SMM. There is no diminution in sensitivity for detecting MM, macroglobulinemia, and LCDD.
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Katzmann et al. (2009) studied this question.
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